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Myelofibrosis of the  bone marrow with replacement of normal marrow by fibrous connective tissue. There is loss of hematopoietic cells due to fibrosis of the bonemarrow.
Normal healthy bone marrow depicting erythroid and myeloid cells
Squamous cell carcinoma of lung (left half of image) replacing normal healthy lung tissue (right side) with many tumor cell undergoing mitotic cell division
Normal healthy parathyroid gland (right half) embedded within and attached to the thyroid gland (left half). The thyroid gland is made of pink follicles containing thyroxine hormone.
Microscopic view of bone marrow biopsy from myelodysplastic condition. Part of the bone is visible on the right (pink).
Normal healthy glomeruli (left) with glomerulosclerosis (right) a condition with fibrosis (scar) of the glomeruli (blue stain). The thin loops of blood vessels are replaced by the blue scar tissue.
Parathyroid gland (blue oval tissue) embedded within thyroid gland (pink). Inset shows a magnified view of the parathyroid gland cells. Parathyroid gland is important in calcium and bone homeostasis
Paired adrenal glands showing the central (blue) medulla, surrounded by cortex with three distinct zones from out to inside - zona glomerulosa, fasciculata (pale zone in the middle), and reticularis
Pepsinogen enzymes in stomach glands (brown)
Highly magnified microscopic view of small intestine (duodenum) with enteritis in immunodeficiency status
Normal muscle (left) and muscle from Muscular Dystrophy (right) showing degeneration and necrosis of fibers (blue/gray fibers)
Cross section of normal healthy tongue showing the central core of muscles surrounded by epithelial cells forming numerous papillae (small projections on the outer surface).
Bronchiolar lavage fluid showing pneumocystis carinii (round fungal organisms). Cytology of intracellular and extracellular fungi from lung aspirate
 Toxoplasmosis with Toxoplasmsa gondii within macrophages from a cytology smear. Clusters of parasitic organisms are within macrophages.
Myocarditis due to Trypanosoma Cruzi. Inflammation of the heart due to parasitic protozoan parasite Trypanosoma. Chagas disease.  Inset shows numerous protozoan parasites within the heart fibers.
Normal healthy testis with multiple cross sections of seminiferous tubules with active spermatogenesis showing germ cells, spermatids, spermatocytes, Sertoli cells and spermatozoa in tubules.
Severe fungal pneumonia (aspergillous) due to immunocompromised state. The fungal hyphae are present as radiating filaments stained light blue to gray.
Mouse heart anatomy
Lung with pulmonary artery containing thrombus due to thromboembolism. Reorganization of the thrombi (right) and congestion of the alveoli. Thrombosis of lung.
Blood smear to show myelomonocytic leukemia. The smear shows large number of cancer leukemia cells (large blue cells) with the smaller red to pink normal red blood cells or erythrocytes.
GI Tract anatomy - Normal healthy esophagus (top left), stomach (top right), small intestine (bottom left) and large intestine (bottom left). The four structures of the gastrointestinal tract.
Open air wooden gazebo overlooking a pond an ideal place for picnics, photo shoots and engagement pictures
Cytology smear of pleural effusion showing candida (fungi) organism mixed with white blood cells. Fungal hyphae are present in the smear along with leukocytes and protein.
Malignant smooth muscle tumor leiomyosarcoma with bundles of cancer cells composed of smooth muscle fibers arranged in streaming bundles with mitosis
Severe bacterial  (shigella, salmonella, cholera) infection of the intestines resulting in enteritis with ulcers of the intestinal mucosal lining and bacterial colonies adherent to the dead tissue.
Actinic keratosis and squamous cell carcinoma of skin showing squamous cell carcinoma (in situ) on the left and relatively normal skin on right side of image. Epidermis is thickened on left (cancer).
Colonic adenocarcinoma image with bone formation. The image shows intestinal epithelial cancer with osseous trabeculae and invasion of intestinal wall
Normal healthy liver (left) compared to unhealthy diseased liver (right) with hepatic cirrhosis.
Cellular smear of cryptococcus fungi - lung and nasal cavity cytology showing fugal cryptococcus neoformans organisms with capsule
Melanoma of the skin with ulceration of the epidermal surface and expansion of the dermis by tumor cells containing melanin
Skin biopsy showing solar elastosis and actinic keratosis due to exposure to UV rays, excessive sun exposure. The dermal region contains elastic blue fibers and the epidermis is irregularly thickened
Normal healthy artery (left) compared to disease artery due to pulmonary hypertension with massive thickening of the pulmonary artery with thick tunic media.
Normal healthy brown fat (left image) and normal healthy white fat. Brown adipose tissue or hibernating gland with small fat vacuoles (left) and white adipose tissue (right) with large fat vacuoles
Normal healthy urinary bladder with mucosa lined by transitional epithelium.
Metastatic colonic adenocarcinoma in the lymph node. Lymph node with metastasis of intestinal carcinoma (top half of image) with normal lymph tissue on the bottom. Mucinous intestinal cancer
Highly magnified view of bone eating multinucleated osteoclasts along scalloped edges of trabecular bone due to osteoclastic bone resorption
Metastatic myeloid leukemia in the liver. The metastatic cancer cells (small blue cells) are invading and replacing normal liver cells.
Fat infiltration of the heart. Fatty infiltration of the myocardium - fat cells infiltrating the cardiac tissue replacing myocytes with fibrosis. Fibrofatty myocardium
Normal healthy heart tissue (left) compared to heart muscle with metastatic lymphoma (right). The cardiac muscle is replaced by infiltrating neoplastic (tumor) cells that are stained blue.
Cancer of the breast stained for HER-2 and cytokeratin
Golden hall room inside the City Hall in Stockholm where the Nobel prize winners are thrown a dinner and dance banquet
Congenital hepatic fibrosis of the liver showing bands of blue fibrous (scar) tissue connecting multiple liver lobules with marked fibrosis and dilation of bile ducts.
Normal healthy thryoid gland with embedded parathyroid gland (blue island). The inset shows the magnified view of the thyroid and parathyroid gland.
Septic thromoembolism of the lung with organized recanalized thrombus in pulmonary vessel, pulmonary edema, hemorrhage and congested lung alveoli.
Highly magnified view of brain tumor. Oligodendroglioma of the brain. Brain glioma.
Pancreas stained for insulin (red) showing multiple islands of Langerhans containing beta cells stained immunohistochemically for insulin (red island) with ducts stained for cytokeratin (Brown)
Microscopic image of histoplasmosis a fungal infection caused by histoplasma capsulatum. The image show severe granulomatous inflammation with intracellular fungal organisms with yeast like morphology
Ovary showing developing follicles and regressed corpus luteum
Parafollicular (C - cells) of the thyroid gland stained immunohistochemically for calcitonin hormone (brown). The brown stained C-cells are important in calcium and phosphorus mineral balance
Kidney cancer (left) and normal kidney (right). Renal cell carcinoma has replaced normal kidney tissue and the cancer has many areas of tissue death (necrosis).
Pulmonary amyloidosis with deposits of pale gray to light pink amyloid protein in blood vessel wall, alveoli. Pneumocytes the lung epithelial cells are prominent.
Normal healthy lung (left) and lung with emphysema (right) showing expanded alveoli (air spaces) thickened smooth muscle. Emphysematous lung has ruptured alveolar spaces.
Lady Liberty with the background sky in a radiating pattern. Statue of Liberty.
Endometriosis - Image illustrates uterine endometrium infiltrating the intestinal wall (blue islands of epithelium and stroma in the pink intestinal wall). Inset - magnified view of endometrial gland
Hepatocytes undergoing mitosis with apoptosis (bottom right image). Cell division and cell death of hepatocyte (Liver cell). Prophase, metaphase, anaphase, telophase stages of mitotic cell division.
Normal healthy lymph node (left) and lymph node architecture obliterated by lymphoma (right) with sheets of cancer cells. Normal healthy lymphoid follicles with germinal centers in the left image.
Bone forming cells osteoblasts lining the surface of mature cortical bone (pink substance in bottom half is bone). The bone has mature osteocytes in lacunae
Lupus erythematosus cell
Microscopic view of normal healthy joint (left) when compared to joint with osteoarthritis with loss of articular cartilage, fibrosis, inflammation and loss of bone (right).
Normal healthy endocrine organs with pituitary (top left), paired thyroid glands with embedded parathyroids (top right), paired adrenal glands (bottom left) and pancreatic islets (bottom right)
Skin lesion from a case of pemphigus foliaceus. The epidermal blister contains exfoliated corneocytes or keratinocytes and neutrophils.
Sperm (spermatozoa) viewed under the microscope
Pneumonia due to toxoplasmosis with fibrin deposits within alveoli and parasitic organisms within macrophages (green arrow).
Normal healthy nerve (left) compared to nerve with axonal degeneration of the nerve fiber (right) showing nerve injury. Wallerian degeneration of nerve fibers.
Acute necrosis (cell death) of the liver cells - the wide uniform band of pink cells are dead (necrotic) while the darker cells on the periphery are normal and healthy. Centrilobular hepatic necrosis
Transverse (cross sectional) view of the female reproductive system with the vagina (far left), cervix (middle) and the uterus (far right). The mucosa (lining epithelium) is different.
Hepatocellular carcinoma - Liver cancer (right half).  Liver tumor composed of irregular cords with blood filled cystic spaces. Poor demarcation between normal liver on left and cancer on right.
Lymph node smear showing Trypanosoma Cruzi (parasitic organisms) - Chagas disease
Ependymoma (bottom) a type of brain tumor arising from the ependymal cells in the ventricles and choroid plexus. The pink part on top is normal brain tissue invaded bu tumor cells.
The four key organs that make up the lymphoid system with bone marrow (upper left), lymph nodes (upper right), spleen (lower right) and thymus (lower left). Normal healthy organs are shown.
Cutaneous abscess caused by Staph aureus with expansion of the dermis by a pus filled pocket containing bacteria. The cenral core of the pustule is filled with neutrophils and necrotic tissue.
Normal healthy knee joint with articular cartilage of femur and tibia on either side, with synovium supported by fat in the middle. a portion of joint capsule is on the top.
Dermal leiomyosarcoma a smooth muscle tumor containing massive bundles of neoplastic smooth muscle cells in a streaming fashion. Muscle tumor of the subcutaneous tissue with overlying epidermis
Midline (sagittal) cut through a fresh dissected dog brain.
Normal healthy lung (right) and lung with metastatic lymphoma (left) with sheets of cancer cells filling up alveoli and bronchioles.
Healthy breast tissue stained for cytokeratin
Osteoclasts (bone eating cells) lining scalloped edges of bone. Each osteoclast cell has multiple nuclei. See also osteoblasts.
Mesothelium cells on lung surface
Lymph node from a case of endometriosis. Inset shows higher magnification of endometrial glandular structures.
Tissue Microarray - a pathology technique to screen muliple tissue samples for biomarkers especially cancer prognostic markers on biopsy samples.
Skin lesion from a case of pemphigus foliaceus. The epidermal blister contains exfoliated corneocytes or keratinocytes and neutrophils.
Pancreatic islet - Islet of Langerhans
Normal healthy lymph node (left) compared with lymph node with severe depletion and loss of disease fighting lymphocytes (right) that can lead to immunodeficiency.
Blood smear showing parasitic babesia (blue color) on red blood cells
Polycystic kidney disease with massively dilated renal tubules and a few remnant glomeruli are present.
Infarction of the salivary gland (bottom) with normal healthy salivary gland (top) for comparison. Salivary gland necrosis with vascular thrombosis and ischemic coagulative necrosis of acini.
Normal healthy heart tissue (red stained fibers) is replaced by scar tissue (blue stained) in a congestive heart failure
Heinz bodies on red blood cells
Nerve sheath tumor with slender spindle shaped tumor cells forming herring bone pattern with swirls of neoplastic cells and abundant collagen fibers.
Retina microscopic anatomy
Transverse section of female urethra - central urinary canal lined by urethral epithelium (transitional), a thick band of smooth muscle (blue/gray) and an outer band of striated (red) muscle fibers.
Immature (left) and mature ovary (right). The immature ovary does not have corpus luteum while the mature ovary has a large corpus luteum (large circular structure) that is formed after ovulation.
Fishing from the beach in Outer Banks North Carolina
Normal healthy urinary bladder (top) and urinary bladder with metastatic lymphoma (bottom) with sheets of cancer cells replacing the surface of the bladder mucosa
Leukemia (blue cells) in a blood smear
Normal Kidney (left) and Abnormal Kidney (renal failure) showing scarring (blue)
Thyroid gland histology
Normal healthy lung (left image) contrasts with lung showing sever inflammation and injury due to bleomycin (right image) due to chemotherapy. There is fibrosis, infllammation, and fluid accumulation.
Amyloid deposition in the walls of the pulmonary blood vessels.  Pulmonary artery is expanded by pale gray to light pink amyloid protein and normal smooth muscle cells are lost.
Microscopic view of oligodendroglioma of the brain (right half in blue) and normal brain (pink portion on left). The brain cancer has invaded and replaced normal healthy brain tissue. Glioma of brain.
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