Juan Gaertner

Juan Gaertner

I'm a graduate chemist and 3d-artist specialized in scientific visualisation and animation.
Germany
Germany

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426 stock photos, vectors, and illustrations are available royalty-free.

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Candida yeasts. C. albicans and C. auris are two pathogenic yeasts that cause candidiasis. C. auris has acquired multiple drug resistance. It's infection can end deadly.  3d rendering
Alzheimer's disease: the amyloid-beta peptide accumulates to amyloid fibrils that build up dense amyloid plaques. 3d rendering
RNA polymerase is composed of several proteins. It unwinds DNA strands (violet) and builds RNA (red) out of the nucleotides uridine, adenosine, cytlidine and guanosine monophosphate. 3d rendering
After activation by antigen presenting cells, T helper cells segregate several cytokins IL-4, IL-5, IL-6, IL-9, IL-10 and IL-13, Source: PDB entries 2B8U, 3VA2, 1ALU, 2H24, 3BPO, 3d rendering
The insulin receptor (blue) is a transmembrane protein, that is activated by insulin (orange) These leads to the transport of glucose into the cell mediated by a glucose tranporter (red). 3d rendering
The coronavirus spike protein (red) mediates the virus entry into host cells. It binds to the angiotensin converting enzyme 2 (blue) and fuses viral and host membranes. PDB entry 6cs2. 3d rendering
Proteasome degrading a protein (red) tagged with polyubiquitin.  They degrade unneeded or damaged proteins that have been tagged with polyubiquitin (yellow). Source PDB entry 5GJQ. 3d rendering
A microglia cell. It plays an important role in the pathogenesis of Alzheimer's disease. Microglia are specialised macrophages that restrain the accumulation of amyloid plaques (orange). 3d rendering
Insulin molecules. Insulin is a protein hormone that regulates the metabolism of carbohydrates and fats.   3d rendering
PETase is a bacterial enzyme that breaks down PET-plastic to monomeric molecules. The whole bacterial degradation process yields environmentally harmless products. 3d rendering
Alzheimer's disease: Pathological Tau protein (red-orange) phosphorylation (yellow) leads to disintegration of microtubuli and aggregation to neurofibrillary tangles (orange) in a neuron axon.
Insulin receptor inactivated, insulin is close to the binding site. Insulin binding activates a signal cascade leading to the transport of glucose into the cell. 3d rendering
Activation of the immune response: antigen presenting cell activates T-lymphocytes (smaller  cells).  Magnification: T-cell receptor in complex with an MHC class II molecule and an antigen. 3d renderi
 Insulin (orange) bound to the insulin receptor (blue). Insulin binding induces structural changes within the receptor leading to the transport of glucose molecules into the cell. 3d rendering
Microglia cells (red) play an important role in the pathogenesis of Alzheimer's disease. Microglia are specialised macrophages that restrain the accumulation of amyloid (orange plaques). 3d rendering
Tapeworm in human intestine. 3D rendering.
Tapeworms are a species of parasitic flatworms. They live in the digestive tracts of vertebrates.
Interleukin 13 binds to the IL-13-receptor. It is a mediator of allergic inflammation and different diseases including asthma, mucus hypersecretion, fibrosis, airway hyperresponsiveness. 3d rendering
Colon affected by ulcerative colitis, 3d rendering.
The ulcerative colitis is an inflammatory disease of the human bowel.
Chimeric antigen receptor therapy,
CAR molecules (light blue) bind to CD19 molecules on a leukemia cell leading to segregation of granzyme vesicles (yellow) that activate the apoptosis, 3d rendering
Large roundworm in human intestine.
Ascaris lumbricoides lives in the intestines.The larvae penetrate the intestine wall, enter the blood stream and infestate several organs. 3d rendering
After activation by an antigen presenting cell, a T helper cell segregates the cytokines IL-4, IL-5, IL-6, IL-9. IL-10 and IL-13. Source: PDB entries 2B8U, 3VA2, 1ALU, 2H24, 3BPO. 3d rendering
Insulin receptor inactivated (left) and activated (right), after insulin binding. Insulin binding activates a  signal cascade leading to the transport of glucose into the cell. 3d rendering
Intestine affected by Morbus Crohn. 3d rendering.
Crohn's disease is an inflammatory bowel disease, it causes abdominal pain, diarrhea and vomiting.
Activation of a Ras protein
Inactive Ras protein (left) is activated by a GEF protein opening the binding site allowing GDP to exit. Then GTP can bind to RAS turning it into the active form. 3d render
T-cell receptor, CD-4, CD-28, PD-1 and CTLA-4 and a calcium channel on a T-cell 
TCR (blue), CD-4 (light blue), CD-28 (dark blue),  PD-1 (magenta), CTLA-4 (violet), Ca-channel (violet), 3d rendering
Tapeworm head attached to the intestine. 3D rendering.
Tapeworms are a species of parasitic flatworms. They live in the digestive tracts of vertebrates.
Different structures of membrane proteins: (left to right) Potassium channel, delta-opioid receptor, LDL receptor, acetylcholine receptor, histamine receptor, 3d rendering
Cancer cell attacked by lymphocytes
The chemokine receptor 5 with a bound antagonist.The HIV1-coreceptor CCR5, is an attractive target  for preventing the entry of human immunodeficiency virus. Source: PDB entry 4mbs. 3d rendering
T-lymphocytes and dendritic cells, 3D-rendering;
Dendritic cells  are antigen-presenting cells of the immune system. They process antigen material and present it on the cell surface to the T-cells.
Activated Ras protein attached to the cell membrane. Ras proteins tansmit signals within cells  turning on genes involved in cell growth, differentiation. Mutations can lead to cancer. 3d Rendering.
THC molecules binding to the cannabinoid receptor. The receptor appears mainly in the nervous system and is involved in appetite, pain-sensation, mood and memory. 3d rendering
Dividing stem cells in the bone marrow, 3D-rendering
Antibody.
Antibodies are proteins produced by plasma cells. They identifiy and neutralize bacteria and viruses. Antibodies recognize unique molecules of the pathogen, called antigens. 3d rendering
Visceral fat is highly hormonally active. 3d rendering
Colorectal cancer. 3d rendering.
The SARS-CoV-2 RNA dependent RNA polymerase is a promising target for the treatment of COVID-19. R2Rp is an enzyme that catalyzes the replication of RNA from an RNA template. PDB 7BTF. 3d rendering
Healthy gut. 3D Rendering.
Insulin molecules.
Insulin is a protein that regulates the metabolism of carbohydrates and fats through the assimilation of glucose. Insulin dimer: Source: PDB entry 1TRZ. 3d rendering
LDL particles in the blood stream Low-density lipoprotein (LDL) particles transport the water insoluble lipids in blood plasma from the liver to other organs and tissues.
View of the cell nucleus in the interphase (DNA, mRNA, nucleolus and several enzymes)
Stem cells
Structure of a low density lipoprotein (LDL)
protein ApoB 100 (blue), phospholipids (orange with a blue cap), cholesterol (orange with a violet cap), triglycerides and cholesteryl esters (yellow)
Dendritic cell. 3D-rendering.
Dendritic cells  are antigen-presenting cells  of the immune system.
Macrophag engulfing bacteria (cocci), 3D rendering.
Macrophages engulf and digest cellular debris and pathogens.
Alzheimer disease: neuron with amyloid plaques,
High density lipoprotein (HDL)
color code: protein ApoA (green), phospholipids (orange with a blue cap), cholesterol (orange with a violet cap)
Carboniferous forest
Fat cells, 3d rendering.
White fat cells contain a large lipid droplet (yellow) and a nucleus (red) located in the periphery.
Arteriosclerosis (4 phases)
Candida auris causes candidiasis, an infection of the bloodstream, the central nervous system and internal organs. It has acquired multiple drug resistance. 3d rendering
Oligodendrocyte forms insulating myelin sheaths around neuron axons in the central nervous system. Myelin increases the impulse speed and decreases the capacitance of the axon membrane. 3d rendering
Cancer cell and lymphocytes
CRISPR-Cas9: The Cas9 enzyme in complex with RNA (yellow) and single stranded DNA (violet). It is used as a specific and easy way to edit genes. Source: PDB entry 5b2r. 3d rendering
Binding of antibodies to the spike (S)-protein of the SARS-CoV-2 virus is an essential  step for  developing immunity to the coronavirus.PDB 1igt. 3d rendering
Coronaviruses budding out of infected pneumocytes type II in a human lung. The darker cells are pneumocytes type I. 3d rendering
Macrophages approaching bacteria (bacilli), 3D rendering.
Multiple sclerosis (MS): microglia cells (orange) damage the myelin sheath of neuron axons leading to a loss of the nerve function. 3d rendering
MDM2 (violet) controls the action of p53 tumor suppressor (blue), which cannot bind to DNA and trigger the self-destruction of the cell. Ubiquitin (yellow)  targets p53 for destruction. 3d rendering
Microglia cell and neuron. Microglial cells are specialised macrophages. They are constantly scavenging the central neuron system for plaques, damaged neurons and infectious agents. 3d rendering
Cancer cell being destroyed by cytotoxic T cells.
Natural killer cells are a type of lymphocytes which destroy cancer cells and other altered cells releasing cytotoxic granules. 3d rendering
Chromatin strand and isolated nucleosome.
Chromatin is a complex of DNA (yellow) and proteins (blue). Nucleosomes form the fundamental repeating units. Source: PDB entry 3afa. 3d rendering
RNA polymerase unwinds DNA strands (violet) and builds RNA (red) out of the nucleotides uridine, adenosine, cytlidine and guanosine monophosphate. Source: PDB entry 1i6h. 3d rendering
The gastric proton pump H+,K+-ATPase with a proton pump inhibitor (PPI) bound. It is a target for drugs that treat acid-related diseases. Source: PDB entry 5yIu. 3d rendering.
Migraine therapy: monoclonal antibodies block the CGRP-receptor. Calcitonin gene related peptide (yellow) can't bind to its receptor and lead to a widening of cerebral blood vessels, 3d rendering
The nucleotide analog remdesivir is considered a promising antiviral drug  for the treatment of Sars-CoV-2 infections. It causes a decrease in viral RNA production. 2d rendering
Interleukin 4  bound to its receptor on a cell membrane. The IL-4 receptor consists of an alfa (light violet) and a gamma chain. Source: PDB entry 3bpl. 3d rendering
 ATP syntethase couples ATP (red) synthesis from ADP and inorganic phosphate (orange) to a proton gradient (yellow) created across the mitochondrial membrane during cellular respiration. 3d rendering
Dendritic cell  presenting an antigen to  T-lymphocytes. The antigen is a peptide from a tumor cell, bacteria or virus. They present antigens to lymphocytes activating an immune response. 3d rendering
Structure of a T-cell receptor bound to a cell membrane. The T-cell receptor activates the immune response to antigens in T-lymphocytes. 3d rendering
Bacteriophages infecting and killing bacteria. Phages are a possible therapy against multi-drug-resistant bacteria. 3d rendering
Insulin is a protein hormone that regulates the metabolism of carbohydrates and fats through the assimilation of glucose .Source: PDB entry 3I40. 3d rendering

PD-1  (red)  interacts with PD-L1 (yellow) from a antigen presenting cell leading to a down-regulation of the activating interaction of MHC-II (violet) with the T-cell receptor (blue). 3d rendering
Nucleosomes form the fundamental repeating units of eukaryotic chromatin. They consist of DNA wound around eight histone proteins and of about 146 base pairs. Source: PDB entry 3afa.3d rendering
Visceral fat is highly hormonally active. It raises the LDL-level in the blood causing a higher risk of atherosclerosis and stroke. 3d rendering.
Candida albicans can become pathogenic in immunocompromised persons. It causes the infection candidiasis. It's one of the most common hospital acquired infections. 3d rendering
Massive diverticulosis.
Diverticula in the large intestine. Diverticulitis results of the inflammation of one of these diverticula. The most common sympton is abdominal pain. 3d rendering
LDL particles binding to LDL receptors on the cell membrane.
The binding of LDL particles to the LDL receptors mediates the endocytosis of the particles through clathrin coated vesicles. 3d rendering
The calcitonin gene related peptide (yellow) binds to its receptor (blue) on neurons and smooth muscle cells of cerebral blood vessels that  leads to a dilatation of the blood vessels, 3d rendering
After activation by an antigen presenting cell, a T helper cell segregates the cytokines IL-4, IL-5, IL-6, IL-9, IL-10 and IL-13.. Source: PDB entries 2B8U, 3VA2, 1ALU, 2H24, 3BPO. 3d rendering
Interleukin 4 (IL-4) molecules.
IL-4 is a cytokine and a key regulator of the immune system and plays an important role in allergic and asthmatic symptoms. Source PDB entry 2b8u. 3d rendering

Streptoccus bacteria.
Streptococcus species are responsible for pharyngitis, meningitis, bacterial pneumonia, endocarditis and necrotizing fasciitis. 3d rendering
A fibrin monomer is composed of 2α, 2ß, 2γ and 2αC domains. There are 4 flexible chains (light blue) in the center. The 2 short chains bind to two adjacent γ domains of the polymer. 3d rendering.
MDM2 (violet, left side) and MDMX (red) tag the p53 tumor suppressor with ubiquitin (yellow) leading to its degradation into small peptides by a proteasome (violett). 3d rendering
T cells play a key role in the development of long-term immunity. to coronavirus. Helper T cells stimulate B cells and other immune cells.  3d rendering
Immune response to coronavirus infection: coronaviruses marked bei antibodies are engulfed and destroyed by a macrophage immune cell. 3d rendering
2 thrombin molecules (red) activate fibrin by cutting some aminoacid residues (yellow glow) from the flexible arms in the middle of the fibrinogen molecule. PDB entries: 1m1j, 2baf, 2a45. 3d rendering
Immune response to coronavirus infection: coronaviruses marked bei antibodies are engulfed and destroyed by a macrophage immune cell. 3d rendering
Structure of fibrinogen. Fibrinogen is composed of two trimers, and each trimer  oft three polypeptide chains. 2 flexible arms  at either sie. PDB entries: 1m1j, 2baf, 2a45. 3d rendering
Maraviroc binding to the HIV1- coreceptor, CC chemokine receptor 5 (CCR5), prevents it from binding the viral envelope protein gp120, blocking a HIV infection. Source: PDB entry 4mbs. 3d rendering
2 thrombin molecules (red) activate fibrin by cutting some aminoacid residues from the flexible arms of the fibrinogen molecule, causing it to polymerize. PDB entries: 1m1j, 2baf, 2a45. 3d rendering
The voltage-gated ion channel  iscomposed of a large alpha subunit and one or more regulatory beta subunits (dark blue). Source: PDB entry 6AGF. 3d rendering
Pyramidal neurons in the cerebral cortex. Pyramidal neurons 
are found in certain areas of the brain including the cerebral cortex, the hippocampus, and the amygdala. 3d rendering
Multiple sclerosis (MS): heatlhy neuron with intact myelin sheaths (left), neuron affected by MS (right) 
Microglia cells attack the oligodendrocytes that form the  myelin sheath. 3d rendering
Calcitonin gene related peptide (CGRP, yellow) bound to its receptor (left), monoclonal antibody (red) blocking the CGRP receptor. The blocking diminishes the quantity of migraine attacks. 3d render
Structure of fibrinogen. Fibrinogen turns to fibrin by the catalysis of thrombin, that cleaves the short flexible arms. Hence fibrin polymerizes building blood clots. PDB IDs 1m1j, 2baf. 3d rendering
Proteins of coronavirus SARS-CoV-2 that are potential drug target: spike protein (violet), RNA polymerase (orange), main protease (red).  PDB entries: 6vsb, 7btf, 6lu7. 3d rendering
Blood clot (thrombus). Erythrocytes (red blood cells) are trapped within a fibrin mesh. 3d rendering
Immune response to coronavirus infection: coronaviruses marked bei antibodies are engulfed and destroyed by a macrophage immune cell. 3d rendering
Potential drug target proteins of coronavirus SARS-CoV-2. From upper left to right: spike protein, RNA polymerase, main protease with an inhibitor bound.  PDB entries: 6vsb, 7btf, 6lu7. 3d rendering
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