Juan Gaertner

Juan Gaertner

I'm a graduate chemist and 3d-artist specialized in scientific visualisation and animation.
Germany
Germany

Top images

453 stock photos, vectors, and illustrations are available royalty-free.

Sort by
of 5
The coronavirus spike protein (red) mediates the virus entry into host cells. It binds to the angiotensin converting enzyme 2 (blue) and fuses viral and host membranes. PDB entry 6cs2. 3d rendering
RNA polymerase is composed of several proteins. It unwinds DNA strands (violet) and builds RNA (red) out of the nucleotides uridine, adenosine, cytlidine and guanosine monophosphate. 3d rendering
PETase is a bacterial enzyme that breaks down PET-plastic to monomeric molecules. The whole bacterial degradation process yields environmentally harmless products. 3d rendering
Proteasome degrading a protein (red) tagged with polyubiquitin.  They degrade unneeded or damaged proteins that have been tagged with polyubiquitin (yellow). Source PDB entry 5GJQ. 3d rendering
Insulin molecules. Insulin is a protein hormone that regulates the metabolism of carbohydrates and fats.   3d rendering
Candida yeasts. C. albicans and C. auris are two pathogenic yeasts that cause candidiasis. C. auris has acquired multiple drug resistance. It's infection can end deadly.  3d rendering
Oligodendrocyte forms insulating myelin sheaths around neuron axons in the central nervous system. Myelin increases the impulse speed and decreases the capacitance of the axon membrane. 3d rendering
The insulin receptor (blue) is a transmembrane protein, that is activated by insulin (orange) These leads to the transport of glucose into the cell mediated by a glucose tranporter (red). 3d rendering
Immune response to coronavirus infection. Binding of antibodies to the spike (S)-protein of the SARS-CoV-2 virus is an essential  step for  developing immunity to the coronavirus. 3d rendering
Microglia cells (red) play an important role in the pathogenesis of Alzheimer's disease. Microglia are specialised macrophages that restrain the accumulation of amyloid (orange plaques). 3d rendering
Alzheimer's disease: the amyloid-beta peptide accumulates to amyloid fibrils that build up dense amyloid plaques. 3d rendering
After activation by antigen presenting cells, T helper cells segregate several cytokins IL-4, IL-5, IL-6, IL-9, IL-10 and IL-13, Source: PDB entries 2B8U, 3VA2, 1ALU, 2H24, 3BPO, 3d rendering
RNA polymerase unwinds DNA strands (violet) and builds RNA (red) out of the nucleotides uridine, adenosine, cytlidine and guanosine monophosphate. Source: PDB entry 1i6h. 3d rendering
The mitotic kinase NEK7 binds to inactive NRLP3 leading to the assembly and activation of the NLRP3 inflammasome. Source: PDB entries 2WQM, 6NPY.3d rendering
Alzheimer's disease: Pathological Tau protein (red-orange) phosphorylation (yellow) leads to disintegration of microtubuli and aggregation to neurofibrillary tangles (orange) in a neuron axon.
Tapeworm in human intestine. 3D rendering.
Tapeworms are a species of parasitic flatworms. They live in the digestive tracts of vertebrates.
Binding of the coronavirus spike protein(red)  to an ACE2 receptor (blue) on a human cell  leads to the penetration of the virus in the cell, as depicted in the background. 3d rendering. PDB 3sci
Maraviroc binding to the HIV1- coreceptor, CC chemokine receptor 5 (CCR5), prevents it from binding the viral envelope protein gp120, blocking a HIV infection. Source: PDB entry 4mbs. 3d rendering
 Alzheimer: Pathological phosphorylation (yellow) of Tau proteins (red-orange) by kinases (violet) leads to disintegration of microtubuli in an axon and to aggregation of the tau proteins.

Streptoccus bacteria.
Streptococcus species are responsible for pharyngitis, meningitis, bacterial pneumonia, endocarditis and necrotizing fasciitis. 3d rendering
Coronaviruses penetrating in human cell. Binding of the coronavirus spike protein(red)  to an ACE2 receptor (blue)  leads to the penetration of the virus in the cell. 3d rendering. PDB 6VSB, 6ACJ
The chemokine receptor 5 with a bound antagonist.The HIV1-coreceptor CCR5, is an attractive target  for preventing the entry of human immunodeficiency virus. Source: PDB entry 4mbs. 3d rendering
MDM2 (violet, left side) and MDMX (red) tag the p53 tumor suppressor with ubiquitin (yellow) leading to its degradation into small peptides by a proteasome (violett). 3d rendering
A microglia cell. It plays an important role in the pathogenesis of Alzheimer's disease. Microglia are specialised macrophages that restrain the accumulation of amyloid plaques (orange). 3d rendering
 ATP syntethase couples ATP (red) synthesis from ADP and inorganic phosphate (orange) to a proton gradient (yellow) created across the mitochondrial membrane during cellular respiration. 3d rendering
Colon affected by ulcerative colitis, 3d rendering.
The ulcerative colitis is an inflammatory disease of the human bowel.
The calcitonin gene related peptide (yellow) binds to its receptor (blue) on neurons and smooth muscle cells of cerebral blood vessels that  leads to a dilatation of the blood vessels, 3d rendering

PD-1  (red)  interacts with PD-L1 (yellow) from a antigen presenting cell leading to a down-regulation of the activating interaction of MHC-II (violet) with the T-cell receptor (blue). 3d rendering
The tumor suppressor p53 (blue) tagged with ubiquitin (yellow) is degraded into small peptides by a proteasome  (violet). 3d rendering
Interleukin 4 (IL-4) binds to its receptor. IL-4 is a key regulator of the immune system and plays an important role in the development of allergic hypersensitivity. 3d rendering
LDL particles binding to LDL receptors on the cell membrane.
The binding of LDL particles to the LDL receptors mediates the endocytosis of the particles through clathrin coated vesicles. 3d rendering
Vancomycin, binds to the peptide chains of a peptidoglycane. Thus, the D-alanyl-D-lactate ligase (blue) cannot build up the bacterial wall, leading to the death of the bacteria. PDB 1e4e. 3d rendering
Tapeworm in human intestine, magnification of the head attached to the intestine.3D rendering.
Tapeworms are a species of parasitic flatworms. They live in the digestive tracts of vertebrates.
Insulin is a protein hormone that regulates the metabolism of carbohydrates and fats through the assimilation of glucose .Source: PDB entry 3I40. 3d rendering
Cancer cell being destroyed by cytotoxic T cells.
Natural killer cells are a type of lymphocytes which destroy cancer cells and other altered cells releasing cytotoxic granules. 3d rendering
CRISPR-Cas9: The Cas9 enzyme in complex with RNA (yellow) and single stranded DNA (violet). It is used as a specific and easy way to edit genes. Source: PDB entry 5b2r. 3d rendering
 Insulin (orange) bound to the insulin receptor (blue). Insulin binding induces structural changes within the receptor leading to the transport of glucose molecules into the cell. 3d rendering
The mitotic kinase NEK7 binds to inactive NRLP3 leading to the assembly and activation of the NLRP3 inflammasome. Source: PDB entries 2WQM, 6NPY. 3d rendering
Chromatin strand and isolated nucleosome.
Chromatin is a complex of DNA (yellow) and proteins (blue). Nucleosomes form the fundamental repeating units. Source: PDB entry 3afa. 3d rendering
The gastric proton pump H+,K+-ATPase with a proton pump inhibitor (PPI) bound. It is a target for drugs that treat acid-related diseases. Source: PDB entry 5yIu. 3d rendering.
Vancomycin resistance: D-alanyl-D-lactate ligase (blue) synthesizes cell-wall precursors in bacteria, that are resistant to the antibiotic vancomycin (yellow). Source: PDB entry 1e4e.  3d rendering

Membrane proteins involved in  the activation and inhibition of the immune system through the interaction of antigen presenting cells and T-cells. 3d rendering
Activation of the immune response: antigen presenting cell activates T-lymphocytes (smaller  cells).  Magnification: T-cell receptor in complex with an MHC class II molecule and an antigen. 3d renderi
The voltage-gated ion channel  iscomposed of a large alpha subunit and one or more regulatory beta subunits (dark blue). Source: PDB entry 6AGF. 3d rendering
Healthy gut. 3D Rendering.
p53 bound to DNA
p53 prevents cancer formation and acts as a guardian of the genome. Mutations in the p53 gene contribute to about half of the cases of human cancer. 3d rendering
Potential drug target proteins of coronavirus SARS-CoV-2:spike protein, RNA polymerase, main protease.From left : spike protein, RNA polymerase, main protease. PDB ID: 6vsb, 7btf, 6lu7. 3d rendering
The T-cell receptor activates the immune response to antigens in T-lymphocytes.
T-cell  receptors (dark blue), CD4 molecules (light blue), glycolipids (orange).  3d rendering
Interleukin 13 binds to the IL-13-receptor. It is a mediator of allergic inflammation and different diseases including asthma, mucus hypersecretion, fibrosis, airway hyperresponsiveness. 3d rendering
Insulin receptor inactivated, insulin is close to the binding site. Insulin binding activates a signal cascade leading to the transport of glucose into the cell. 3d rendering
Insulin receptor inactivated (left) and activated (right), after insulin binding. Insulin binding activates a  signal cascade leading to the transport of glucose into the cell. 3d rendering
Chimeric antigen receptor therapy,
CAR molecules (light blue) bind to CD19 molecules on a leukemia cell leading to segregation of granzyme vesicles (yellow) that activate the apoptosis, 3d rendering
Large roundworm in human intestine.
Ascaris lumbricoides lives in the intestines.The larvae penetrate the intestine wall, enter the blood stream and infestate several organs. 3d rendering
Interleukin 4  bound to its receptor on a cell membrane. The IL-4 receptor consists of an alfa (light violet) and a gamma chain. Source: PDB entry 3bpl. 3d rendering
T-cell receptor, CD-4, CD-28, PD-1 and CTLA-4 and a calcium channel on a T-cell 
TCR (blue), CD-4 (light blue), CD-28 (dark blue),  PD-1 (magenta), CTLA-4 (violet), Ca-channel (violet), 3d rendering
Intestine affected by Morbus Crohn. 3d rendering.
Crohn's disease is an inflammatory bowel disease, it causes abdominal pain, diarrhea and vomiting.
Activation of a Ras protein
Inactive Ras protein (left) is activated by a GEF protein opening the binding site allowing GDP to exit. Then GTP can bind to RAS turning it into the active form. 3d render
Structure variety of membrane proteins: 
(left to right) Potassium channel, delta-opioid receptor, LDL receptor, acetylcholine receptor, histamine receptor, 3d rendering
Two brain cell receptors: delta opioid receptor and cannabinoid receptor
The opioid and cannabinoid  receptors are involved in pain-sensation, mood, appetite and memory. 3d rendering
Plasma cells (B-cells) segregate specific antibodies to mark an subsequently destroy viruses (influenza viruses).3D rendering.
Candida albicans can become pathogenic in immunocompromised persons. It causes the infection candidiasis. It's one of the most common hospital acquired infections. 3d rendering
The nucleotide analog remdesivir blocks the SARS-CoV-2 RNA dependent RNA polymerase and is a promising drug for the treatment of COVID-19. PDB entry 7BTF, 3d rendering
Tapeworm head attached to the intestine. 3D rendering.
Tapeworms are a species of parasitic flatworms. They live in the digestive tracts of vertebrates.
Massive diverticulosis.
Diverticula in the large intestine. Diverticulitis results of the inflammation of one of these diverticula. The most common sympton is abdominal pain. 3d rendering
After activation by an antigen presenting cell, a T helper cell segregates the cytokines IL-4, IL-5, IL-6, IL-9, IL-10 and IL-13.. Source: PDB entries 2B8U, 3VA2, 1ALU, 2H24, 3BPO. 3d rendering
RNA polymerase unwinds DNA strands (violet) and builds RNA (red) out of the nucleotides  adenosine (magenta), cytlidine (violet), guanosine (yellow) and uridine (white) monophosphate. 3d rendering
Staphylococcus aureus bacteria populate the cracked skin of neurodermatitis patients and aggravate the neurodermatitis symptoms. 3d rendering
After activation by an antigen presenting cell, a T helper cell segregates the cytokines IL-4, IL-5, IL-6, IL-9. IL-10 and IL-13. Source: PDB entries 2B8U, 3VA2, 1ALU, 2H24, 3BPO. 3d rendering
The coronavirus 3CL hydrolase, aka main protease, with an inhibitor in the active site. It is essential for the maturation of the virus and can be a promising target for drugs. 3d rendering. PDB 6LU7
Insulin resistance, insulin receptors (blue) cannot respond properly to the hormone insulin (orange). Glucose (yellow) cannot  be transported into the cell by glucose transporters (red).  3d rendering
Visceral fat is highly hormonally active. 3d rendering
The AMPA glutamate receptor activated by glutamate. The neurotransmitter glutamate (orange) activates the receptor to transport cations (red) into a neuron. Source: PDB entry 3kg2. 3d rendering
Pyramidal neurons in the cerebral cortex. Pyramidal neurons 
are found in certain areas of the brain including the cerebral cortex, the hippocampus, and the amygdala. 3d rendering
Antidepressive drug (amitriptyline) binding to and blocking a neuronal sodium channel. Sodium channels generate and propagate action potentials in neurons and muscle. Source: PDB entry 6. 3d rendering
The SARS-CoV-2 RNA dependent RNA polymerase is a promising target for the treatment of COVID-19. R2Rp is an enzyme that catalyzes the replication of RNA from an RNA template. PDB 7BTF. 3d rendering
HIV-1 reverse transcriptase (RT) complexed with 30 nucleoside inhibitor (orange), 3d rendering
Antibodies binding to the spike protein (red) of the coronavirus prevent it's binding to ACE2 (light blue) on a human cell. The virus can't penetrate anymore in the cell. PDB 1igt 6vsb. 3d rendering
A domain (gp120, violet) of the HIV-1 envelope protein interacts with the CD4 receptor (dark blue) and a chemokine receptor (CCR5, light blue) of an immune cell. Source: PDB entry 6MEO. 3d rendering
Microglia cell and neuron. Microglial cells are specialised macrophages. They are constantly scavenging the central neuron system for plaques, damaged neurons and infectious agents. 3d rendering
Structure of a low density lipoprotein (LDL)
protein ApoB 100 (blue), phospholipids (orange with a blue cap), cholesterol (orange with a violet cap), triglycerides and cholesteryl esters (yellow)
Cancer cell attacked by lymphocytes
Calcitonin gene related peptide (CGRP, yellow) bound to its receptor (left), monoclonal antibody (red) blocking the CGRP receptor. The blocking diminishes the quantity of migraine attacks. 3d render
Dividing stem cells in the bone marrow, 3D-rendering
Activation of the immune response to an antigene (green) through the complex between a T-cell receptor (dark blue), an MHC II-antigen (violet) and a CD4 protein (light blue). 3d rendering
A fungal lanosterol 14-alpha demethylase with fuconazole bound to the active site. The magnification shows fluconazole interacting with a heme group. Source: PDB entry 5esf. 3d rendering
3d computer illustration of dividing stem cells. Stem cells are undifferentiated cells that can specialized through mitosis to many other cell types of multicellular organisms. 3d rendering
Plasma cells (B-cells) segregate specific antibodies to mark an subsequently destroy viruses (influenza viruses). 3d rendering
Dust mites in a pillow
T-lymphocytes and dendritic cells, 3D-rendering;
Dendritic cells  are antigen-presenting cells of the immune system. They process antigen material and present it on the cell surface to the T-cells.
Interactions of MHC-II with the T-cell receptor and CD4  and B7-1 with CD-28 activates T-cells while the interactions of P7-1 with CTLA-4  and PD-L1  with PD-1 deactivates T-cells. 3d rendering
Chimeric antigen receptor:
Engineered receptors (light blue) on the surface of a T-lymphocyte bind specifically to CD19-antigen molecules (violet) on a leukemia cell. 3d rendering
MDM2 (violet) controls the action of p53 tumor suppressor (blue), which cannot bind to DNA and trigger the self-destruction of the cell. Ubiquitin (yellow)  targets p53 for destruction. 3d rendering
White matter in the brain and spinal cord: neurons with myelinated axons, oligodendrocytes forming the myelin sheaths, fibrous astrocytes (dark blue) and microglia cells (violet). 3d rendering
Dividing stem cells.
Stem cells are undifferentiated cells that can specialized through mitosis to many other cell types of multicellular organisms.
Drug resistance: Due to mutations in the active site (red), fluconazole can't bind to the lanosterol 14 alpha-demethylase, while the substrate lanosterol (violet)  still does. PDB 5esf. 3d rendering
Ras activation
Inactive Ras protein (left) is activated by a GEF protein opening the binding site and allowing GDP to exit. GTP can now bind to RAS turning it into the active form(right). 3d rendering
2 thrombin molecules (red) activate fibrin by cutting some aminoacid residues (yellow glow) from the flexible arms in the middle of the fibrinogen molecule. PDB entries: 1m1j, 2baf, 2a45. 3d rendering
Spinal disc herniation
Activated Ras protein attached to the cell membrane. Ras proteins tansmit signals within cells  turning on genes involved in cell growth, differentiation. Mutations can lead to cancer. 3d Rendering.
LDL particles in the blood stream Low-density lipoprotein (LDL) particles transport the water insoluble lipids in blood plasma from the liver to other organs and tissues.
of 5